Genomics, Proteomics and Bioinformatics

Arabidopsis Microarray Facility

The genomics facility is involved in the production of the CATMA DNA microarray and facilitates the use of microarrays for the end-user by providing access to genomics equipments and data analysis tools. More information about ordering and use of CATMA DNA microarray slides can be found here.

CAGE: Compendium for Arabidopsis Gene Expression

The goal of the CAGE consortium is to build a gene expression reference database for Arabidopsis by making use of the Complete Transcriptome MicroArray (CATMA). A compendium of gene expression profiles will be made of samples taken from phenotype-based time series of Arabidopsis thaliana and a collection of landmark mutants.  For more information about this project: CAGE homepage

Bioinformatics

Bioinformatics research at the Molecular Genetics Department focuses on Arabidopsis transcription networks. In addition we offer in house bioinformatics tools for prediction of gene and protein function. Moreover general tools such as a BLAST server, a LIMS system, etc. can be found at http://genomics.bio.uu.nl. For more information or questions contact our Bioinformaticist:
Drs. Henk van den Toorn

Proteomics

Several of the projects carried out at our laboratory involve a proteomics approach. The proteomics part of these studies is carried out in collaboration with the Department of Bio-Molecular Mass Spectrometry of Prof. Dr. Albert Heck, of the Faculties of Pharmacy and Chemistry, University Utrecht. To achieve our goals we use state-of-the-art Mass Spectrometry techniques like LC-MS-MS and MALDI-ToF mass spectrometry to identify proteins involved in various plant-pathogen related processes.

Projects:

Signaling at the host-microbe interface: Pathogen-induced modulation of the plant plasma membrane

A functional proteomics approach to identify phospho-proteins involved in plant innate immunity